Recombinant Human Atrial natriuretic peptide receptor 3 (NPR3), partial

1. NPR3 expression is downregulated by MRCCAT1 in the in metastatic clear cell renal cell carcinoma. PMID: 28659173
2. This study suggested that NPR3 rs2270915 polymorphism was associated with decreased systolic blood pressure level marginally in essential hypertension patients in a Chinese Han population; the polymorphism may function through decreasing NPR3 mRNA expression and ANP level. PMID: 28497617
3. NPR-C gene single nucleotide polymorphisms significantly contribute to CAD susceptibility in the Chinese Han population PMID: 27191271
4. The NPRC genetic variant,Rs1847018, is a genetic marker of essential hypertension. PMID: 26782497
5. This study focused on the natriuretic peptide receptor C gene (NPR3). The correlation analysis between NPR3 and hypertension was replicated in 450 Chinese Dai and 484 Chinese Mongolian individuals. PMID: 26345810
6. Angiotensin II downregulates vascular smooth muscle cell NPR-C gene expression by destabilizing its mRNA. PMID: 25711724
7. Results from this study point to a role for miR-100 in the regulation of NPR3 expression, and suggest a possible therapeutic target for modulation of NP bioactivity in heart disease. PMID: 25736855
8. Data show that natriuretic peptide receptor 3 (NPR3) single nucleotide polymorphism (SNP) is independently associated with diastolic dysfunction and does not appear to be related to alterations in circulating levels of natriuretic peptides. PMID: 24465655
9. The significant change in NPR3 protein was observed for the Arg146 variant allozyme, with 20% of wild-type protein, primarily because of autophagy-dependent degradation. PMID: 23493048
10. polymorphisms or haplotype in NPR3 gene may influence the risk of ischemic stroke or hypertension independently in Chinese population. PMID: 22559095
11. a NPR3 promoter gene variant could have a role on cerebrovascular disease susceptibility PMID: 22995222
12. Report the presence of CNP and its receptors, NPR2/3 in atherosclerotic plaques of human carotid artery, with increased expression of NPR3 in histologically unstable plaques. PMID: 22421372
13. Data found a consistent and significant association between the rs2270915 polymorphism of the NPR3 gene and SBP in diabetic patients. This genetic variation may affect pressure response to changes in dietary sodium. PMID: 21464461
14. integrative genomics approach to a large cohort of medulloblastomas has identified four disparate subgroups (NPR3)with distinct demographics, clinical presentation, transcriptional profiles, genetic abnormalities, and clinical outcome. PMID: 20823417
15. The mRNA levels of natriuretic peptide receptor-C appear to be increased in epicardial adipose tissue independent of their plasma levels in coronary artery disease. PMID: 20691218
16. The novel Npr1 gene 3C variant and the Npr3 gene C(-55) allele are associated with hypertensive family history. PMID: 12872042
17. Atrial natriuretic paptide, purified from medium bathing cells expressing NPR-C, a receptor known to internalize natriuretic peptides, was degraded. PMID: 15459247
18. Novel six-nucleotide repeat polymorphism located 4 base pairs upstream of the major transcriptional initiation site. PMID: 15785005
19. model of hormone recognition and allosteric receptor activation revealed from structural studies of NPR-C [review] PMID: 15911071
20. discussion of NPR-C receptor coupling to different signaling pathways and their regulation [review] PMID: 15911072
21. A structural comparison of complexes of NPC-C with each NP hormones (ANP, BNP, and CNP)reveals that NPR-C uses a conformationally inflexible surface to bind three different, highly flexible, NP ligands. PMID: 16870210
22. The NPRC polymorphism is not an independent determinant of NP concentration in HF. PMID: 17890443
23. the NPR-C receptor is expressed in normal and neoplastic human alpha cells. PMID: 19352691

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HGNC: 7945

OMIM: 108962

KEGG: hsa:4883

STRING: 9606.ENSP00000265074

UniGene: Hs.13528